Endocrine Abstracts

Objective: To evaluate the effect of selenium on autoimmune thyroid diseases through ATPO-titers.Material and methods: Selenium (0.1–0.2 mg/day) was associated to basic treatment of thyroid dysfunctions in 21 female patients with high ATPO-levels (normal<34 U/ml). We followed the thyroid function and ATPO-values usually after 2–6 months of selenium administration.Results: Ten hypo-thyroid patients had Hashimoto’s...

Introduction: Acromegaly and Waldenstrom’s macroglobulinaemia are two rare diseases (about 3–4 and 10 cases/million per year respectively), the association between them is even more infrequent, one case being reported in the available literature.Case report: We present the case of a 74-years-old female (I.I.) suffering with both diseases. In 1997 acromegaly diagnosed by dysmorphic syndrome, than in 2004 hormonal/imagistical investigations (GH a...

Introduction: The association of multiple myeloma (MM) with primary hyperparathyroidism (pHPT) is very infrequent. In addition pHPT may be overlooked or later diagnosed, because on the one hand certain clinical and laboratory characteristics of MM, such as hypercalcaemia, asthenia, osteoporosis and impaired renal function overlap with the elements of pHPT, on the other hand modern pHPT include non-classical (e.g. normocalcemic or mild clinical) forms. We present the case of a ...

The perchlorates block the enzyme NIS, inhibiting iodine accumulation in the thyroid and favour the elimination of intrathyroidal iodine unused for hormone synthesis. Their therapeutical utilisation actually is limited due to the toxicity. In the literature there are different opinions regarding the adverse effects (nephrotic syndrome, irreversible aplastic anemia etc.), but several authors sustain that these appear only after high doses, and after the development of therapeut...

Objective: To evaluate the reliability of GH stimulation tests in multiple pituitary hormone deficiency (MPHD) and isolated GHD.Materials and methods: In 19 children with MPHD, we analysed the results of insulin tolerance test (ITT), clonidine and sleep tests, anthropometric parameters, IGF1, bone age, pituitary hormone levels±MRI. GH provocation tests were repeated after variable periods, mostly 6–24 months. The GH provocation tests were consi...

Iodine deficiency in a geographical area can be quantified not only by urinary iodine excretion, but by the frequency of elevated TSH-levels in newborns, too. We compared the TSH-levels obtained between 2001–2003 with those collected after extension of universal salt-iodization with increased iodine-content (KIO3 34±8.5 mg-/kg) in the whole country (2004–2006). The governmental decision was adopted in 2002, implemented in practice in December 2003, an...

County Mures is a moderate/mild iodine-deficient area, the iodine-prophylaxis having an important role in prevention of IDD. Between 2001–2003 we made a partial screening at 320 pregnant women to detect thy-roid dysfunctions, and in 13% (43 cases) we observed hypo-thy-roidism, the majority being subclinical forms. The most frequent compli-ca-tions were threatened abortion or premature birth, and dys-gra-vidia. We found that even the subclinical hypothyroidism can cause se...

Objective: To study the efficacy of lithium and perchlorate in special cases of hyperthyroidism: thioamide-resistant or iodine-induced thyroxicosis/thyrotoxic pre-crisis, hematological adverse effects of methimazole, leukopenia of other causes.Material and methods: Twenty-seven hyperthyroid patients received lithium carbonate and/or potassium perchlorate, majority after methimazole-therapy (associated with folic acid in leukopenia). We followed the clini...

Our previous studies made between 1999–2003 demonstrated that County Mures is a moderate/mild iodine-deficient geogra-phical area. In 2002 a governmental decision was given for universal iodization of alimentary salt with increased iodine-content, realized during 2004. The aim of our study was to investigate the effect of in-creased iodine-supplementation at school children living in different iodine-deficient areas in County Mures, through urinary iodine excretion (UIE)....